Paradoxical adipose hyperplasia

paradoxical adipose hyperplasia

What is paradoxical adipose hyperplasia?

Paradoxical adipose hyperplasia is a rare, previously unreported side effect of cryolipolysis with an incidence of 0.0051%. No single unifying risk factor has been identified. The phenomenon seems to be more common in male patients undergoing cryolipolysis.

Can cryolipolysis help with paradoxical adipose hyperplasia?

The most important thing to know about treating paradoxical adipose hyperplasia is that additional cryolipolysis treatments are not the answer. Instead, liposuction or, in more severe cases, abdominoplasty (read: tummy tuck) are the most effective ways to improve or completely correct PAH. Be aware that multiple surgeries may be needed.

What is middle middle and lower adipose hyperplasia?

Middle: Ideally, attenuation of superficial fat without skin injury will lead to a gentle depression in the region that was treated. The skin, fascial plane, and deep fat should not be interrupted. Lower: in paradoxical adipose hyperplasia, the deep fat is no longer “contained” by the superficial fat and cells therein grow disproportionately.

What is hyperplasia and what does it mean?

Hyperplasia means overgrowth. In other words, when we get fatter, we do not get more fat cells. However, the fat cells that we have become larger, or hyperplastic. Patients who have high volume liposuction, for example, for a Brazilian butt lift, may never regain the fat where the fat has been harvested.

What is paradoxical adipose hyperplasia (PAH)?

To understand paradoxical adipose hyperplasia (PAH), it’s first important to understand cryolipolysis. Also known as ‘fat freezing’ or by its brand name, CoolSculpting®, the non-invasive body contouring procedure is a controlled cooling technique that works by freezing fat cells at negative 11 degrees Celsius to permanently destroy them.

What is the difference between adipose and hyperplasia?

Paradoxical means surprising, unexpected, or the opposite of what you would expect. Adipose is a medical term for fat. Hyperplasia means overgrowth. In other words, when we get fatter, we do not get more fat cells. However, the fat cells that we have become larger, or hyperplastic.

Is paradoxical adipose hyperplasia associated with cryolipolysis curable?

Paradoxical adipose hyperplasia is a rare adverse event associated with cryolipolysis. No evidence of spontaneous resolution has been described and little has been written about its treatment. The purpose of this report is to share the authors experience treating patients with paradoxical adipose hyperplasia after cryolipolysis.

What is middle middle and lower adipose hyperplasia?

Middle: Ideally, attenuation of superficial fat without skin injury will lead to a gentle depression in the region that was treated. The skin, fascial plane, and deep fat should not be interrupted. Lower: in paradoxical adipose hyperplasia, the deep fat is no longer “contained” by the superficial fat and cells therein grow disproportionately.

What is the difference between adipose and hyperplasia?

Paradoxical means surprising, unexpected, or the opposite of what you would expect. Adipose is a medical term for fat. Hyperplasia means overgrowth. In other words, when we get fatter, we do not get more fat cells. However, the fat cells that we have become larger, or hyperplastic.

What is the pathophysiology of adipose tissue hypertrophy?

Adipocyte hypertrophy is a recognized feature of dysfunctional adipose tissue that is associated with increased cellular stress, decreased metabolic flexibility, and systemic diabetes. The mechanisms that regulate hypertrophy are unclear.

What is paradoxical adipose hyperplasia and how is it treated?

It is called so because the cryolipolysis procedure is expected to reduce the fatty or adipose tissue deposits, which are paradoxically increased (hyperplasia) in this side effect. The symptoms of paradoxical adipose hyperplasia may appear a few days to weeks after cryolipolysis. The treated area feels thicker and firmer.

How does adipose tissue grow?

Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the growth of adipose tissue in obesity.

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